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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Epigenetic silencing and tumor suppressor gene of HAND2 by targeting ERK signaling in colorectal cancer

Fig. 2

Methylated HAND2 silenced expression in CRC. a Most of CRC cells were presented with HAND2 hypermethylation (P < 0.05). b HAND2 mRNA expression was greatly decreased in CRC cells compared to normal colon cell CCD18co, NCM460 or normal cell 293 T of one CRC patient. Decreased HAND2 expression in the tumor tissue (R234T) when comparing to paired normal tissue (R234N) in one CRC patient for example. c, d The protein level of HAND2 was high in paratumor normal colon mucosa (c) while was decreased significant in tumor tissue (d) of CRC patient by IHC assay

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Cell Communication and Signaling

ISSN: 1478-811X