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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Epigenetic silencing and tumor suppressor gene of HAND2 by targeting ERK signaling in colorectal cancer

Fig. 1

Hypermethylated HAND2 was correlated with silenced expression and predicted poor survival. a The methylation levels in tumor were obvious increased than paratumor normal tissue by qMSP (n = 74 pairs, paired t test, P < 0.001, the internal control was ALUC4). b The mRNA expression of HAND2 in tumor were reduced than paratumor normal tissue by qPCP (n = 86 pairs, paired t test, P < 0.001, the internal control was HPRT1). c The mRNA levels of HAND2 was negatively correlated with its methylation levels (n = 61 pairs, paired t test, r2 = 0.217, P < 0.0001). d High HAND2 methylation obtained better 5 year-overall survival (OS) than low methylation by Kaplan Meier curve (P = 0.036, n = 60)

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