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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: CCL7 playing a dominant role in recruiting early OCPs to facilitate osteolysis at metastatic site of colorectal cancer

Fig. 3

Blockage of CCL7 inhibited migration of early OCPs. A qRT-PCR analysis showed mRNA level of CCL7 in primary early OCPs isolated from bone marrow at each timepoints after injection of MC-38. n = 3. B qRT-PCR analysis detected mRNA levels of CCL2, CCL6 and CCL7 in early OCPs cultured in MC-38 CM. n = 3. C, D Transwell analysis showed migration of early OCPs indirectly cultured with early OCPs isolated from bone marrow in normal mice or in mice at 10 days post injection of MC-38 with/without treatment of CCL7 nAb (C) and quantification of migration number of early OCPs (D). n = 6. E Quantification of C using Absorbency analysis. n = 5. **p < 0.01, ***p < 0.001

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Cell Communication and Signaling

ISSN: 1478-811X