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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: CCL7 playing a dominant role in recruiting early OCPs to facilitate osteolysis at metastatic site of colorectal cancer

Fig. 1

Blockage of CCL7 inhibiting osteolysis in bone metastasis of MC-38. A ELISA assay detected concentration of members of CCL family in bone marrow at 10 days post injection of MC-38. n = 4, each sample was pooled from 3 mice. B ELISA assay detected concentration of CCL7 in bone marrow at each timepoints after injection of MC-38 or vehicle. n = 8. C Schematics of treatment with CCL7 nAb after injecting of MC-38 cells. D Safranin O and fast green staining showed the trabecular area at 14 dpi, 21 dpi and 35 dpi after injection of MC-38 or not, with treatment with CCL7 nAb or vehicle (Scale bar = 50 μm) and quantification of trabecular area. n = 6. E TRAP staining showed OC surface at 14 days post injection of MC-38 after treatment with CCL7 nAb or vehicle (Scale bar = 50 μm) and quantification of OC surface/trabecular area. n = 6. **p < 0.01, ***p < 0.001

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Cell Communication and Signaling

ISSN: 1478-811X