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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: tRF-Val-CAC-016 modulates the transduction of CACNA1d-mediated MAPK signaling pathways to suppress the proliferation of gastric carcinoma

Fig. 9

Inhibitor of MAPK signaling pathway (p38 MAPK-IN) significantly reversed the enhancement of tRF-Val-CAC-016 inhibitor on GC proliferation. a–b tRF-Val-CAC-016 inhibitor enhanced the GC proliferation in the CCK-8 assay, which p38 MAPK-IN could partly reverse. c–d tRF-Val-CAC-016 inhibitor promoted the cell replication activity, and p38 MAPK-IN could decline this activity in HGC-27 and NCI-N87. The reversal phenomena also happened in the flow cytometry assays for cell cycle (e–g) and immunoblotting assays for CACNA1d, CyclinD1, CyclinB, c-myc (h–i). *P < 0.05, **P < 0.01, statistically significant

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Cell Communication and Signaling

ISSN: 1478-811X