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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: tRF-Val-CAC-016 modulates the transduction of CACNA1d-mediated MAPK signaling pathways to suppress the proliferation of gastric carcinoma

Fig. 3

tRF-Val-CAC-016 suppressed the proliferation of GC. a–b CCK-8 assays for tRF-Val-CAC-016 mimics, tRF-Val-CAC-016 inhibitor, and oxaliplatin. c–d The ethynyl-2′-deoxyuridine (EdU) assays demonstrated that tRF-Val-CAC-016 could suppress the cell replication activity, but tRF-Val-CAC-016 inhibitor enhanced the replication activity of GC. e–g tRF-Val-CAC-016 adjusted the S phase significantly both in NCI-N87 and HGC-27. h–i tRF-Val-CAC-016 modulated the viability of GC cells in colony formation assays. j–k Immunoblotting assays for CyclinD1, CyclinB, c-myc. *P < 0.05, **P < 0.01, statistically significant

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