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Fig. 10 | Cell Communication and Signaling

Fig. 10

From: tRF-Val-CAC-016 modulates the transduction of CACNA1d-mediated MAPK signaling pathways to suppress the proliferation of gastric carcinoma

Fig. 10

tRF-Val-CAC-016 inhibited tumor proliferation in the NCI-N87 xenografts. a Representative images of NCI-N87 xenografts in vivo. Six mice are included in each group. b–d The results indicated that tRF-Val-CAC-016 declined tumor growth capacity in mice in the aspect of the bodyweight of the xenografts and the tumor volumes. e The PCR results of these resected tumors showed that tRF-Val-CAC-016 agomir significantly increased the expression of tRF-Val-CAC-016 compared with the agomir control group and normal saline (NS) group. f The immunoblotting assays showed the inhibitory effect of tRF-Val-CAC-016 agomir on CACNA1d, c-myc, and cyclinD1. g–h The immunofluorescence staining assays for ki-67 and CACNA1d. i The Immunohistochemistry (IHC) assays demonstrated the low expression of CACNA1d in the tRF-Val-CAC-016 agomir group compared with the agomir control group and normal saline (NS) group. *P < 0.05, **P < 0.01, statistically significant

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Cell Communication and Signaling

ISSN: 1478-811X