|  |  |  |  |  |  |  |  |  | p53 mutation |  | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cell lines | Growth properties | Gene cluster | ER | PR | HER2 | Tumor type | Age(years) | Ethnicity | P53 status | Nature | Site | cDNA discription | Protein | Functional impact | Other genomic alterations |
MCF-7 | Adherent | Luminal |  +  |  +  | – | Adenocarcinoma | 69 | white | WT |  |  |  |  |  | CDKN2A; PIK3CA |
ZR-75–1 | Adherent | Luminal |  +  | – | – | IDC | 63 | white | WT |  |  |  |  |  | – |
SK-BR-3 | Adherent | HER2 +  | – | – |  +  | Adenocarcinoma | 43 | white | MUT | Missense mutations | 5-exon | c.524G > A | p.R175H | Chemoresistance; Angiogenesis; Inflammatory response; Metabolic reprogramming; Genetic Instability; Tumor Cell proliferation; Migration, Invasion and Metastasis | – |
DU4475 | Suspension | TNBC | – | – | – | Carcinoma | 70 | white | WT |  |  |  |  |  | APC; BRAF; RB1 |
MB-231 | Adherent | TNBC | – | – | – | Adenocarcinoma | 51 | white | MUT | Missense mutations | 8-exon | c.839G > A | p.R280K | Chemoresistance; Angiogenesis; Inflammatory response | BRAF; CDKN2A; RAS |
HS578T | Adherent | TNBC | – | – | – | Carcinoma | 74 | white | MUT | Missense mutations | 5-exon | c.469G > T | p.V157F | A novel transcriptome regulation | – |
HCC1937 | Adherent | TNBC | – | – | – | IDC | 23 | white | MUT | Nonsense mutations | 8-exon | c.916C > T | p.R306* |  | BRCA1 |