Fig. 7
From: Reconstruction and analysis of a large-scale binary Ras-effector signaling network
Coverage comparison between the Ras signaling network reconstructed in this work and 3 experimental network sources. a Venn diagram of the protein overlap with the following data: our in-house AP-MS measurements of KRAS-Flag-Tag in Caco2 cells performed by Camille Ternet, proximity ligation assay (BioID) on KRAS in Caco2 cells (Kovalski et al., 2019), and effector-specific AP-MS data from BioPlex database. The total number of proteins is indicated in the parentheses, for each dataset. b Portion of proteins, from each experimental dataset, in common with our reconstructed network (percentages within the sets), and their distribution by layer (stacked bar plots). The proteins belonging to multiple layers are counted the number of times they appear, explaining why the sum of the stacked bar plots exceeds 100%