Fig. 1
From: Reconstruction and analysis of a large-scale binary Ras-effector signaling network
Overview of proteins and interactions of the Ras signaling network. Illustration of the 12 classes of Ras effectors and their downstream targets, categorized according to their cross-class presence (class specific, shared within 6 classes at most, or 7 classes at least). The numbers on the arrows indicate the numbers of interactions from one layer to the following. The normalized sum of downstream PPIs expresses the total PPIs per class divided by the number of effectors