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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Heterocellular N-cadherin junctions enable nontransformed cells to inhibit the growth of adjacent transformed cells

Fig. 4

Nontransformed cells inhibit PDPN expression in adjacent transformed cells. Transformed (MEC-Src, HSC-2, MEC-SrcPdpn) cells were stained with DiI (red). These labeled cells were then plated with unlabeled cells of the same type (alone), nontransformed wild type mouse embryonic cells (MEC), or cadherin knockout mouse embryonic cells (MEC-CdhKo) at a 1:300 ratio. Cultures were grown for 24 h before cells were stained with Hoechst (blue), N-Cdh antibody (green), PDPN antibody (purple), and visualized by confocal microscopy as indicated (scale bars = 50 μm)

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Cell Communication and Signaling

ISSN: 1478-811X