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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Endoplasmic reticulum stress promotes the release of exosomal PD-L1 from head and neck cancer cells and facilitates M2 macrophage polarization

Fig. 3

ER stress is associated with macrophage infiltration and PD-L1 expression in OSCC patients. A Typical immunofluorescence images of PERK-positive cells and CD68-positive macrophages in the paraneoplastic tissues (NT) and OSCC tissues (TT) of patients with OSCC (scale bar = 50 μm) (n = 2–3). B Immunofluorescence staining of PERK-positive cells and PD-L1-positive cells in paraneoplastic tissues (NT) and OSCC tissues (TT) of patients with OSCC (scale bar = 50 μm) (n = 2–3). C and D Quantification of PERK-positive, CD68-positive, and PD-L1-positive staining in (A) and (B). E The mRNA level of PD-L1 in the paraneoplastic tissues (NT) and OSCC tissues (TT) of patients with OSCC (n = 3). F The level of PD-L1 protein in the paraneoplastic tissues (NT) and OSCC tissues (TT) of patients with OSCC. G Quantitative analysis of PD-L1 protein levels in (F) (n = 3–6). H The expression pattern of PD-L1 on CD68 + cells in the paraneoplastic tissues (NT) and OSCC tissues (TT) was measured by immunofluorescence (scale bar = 50 μm) (n = 2–3). I Quantification of CD68 + PD-L1 + cell staining in (H) (**P < 0.01 and ***P < 0.001)

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