Table 1 The effects of circRNAs on molecular and signaling mechanisms involved in GBM progression

circHIPK3

Sponging miRNA -654

IGF2/PI3K/Akt

Upregulated

Induces the proliferation, invasion, and tumor propagation

[115]

Hsa_circ_0067934

–

PI3K/AKT

Upregulated

Induces cancer cell proliferation and metastasis

[116]

circ-AKT3

–

PI3K/AKT

Downregulated

Inhibits the proliferation, radiation resistance and tumorigenicity

[117]

circNT5E

Sponging miRNA -422a

SOX4/PI3KCA

Upregulated

Promoted proliferation, migration, and invasion/Inhibits the apoptosis

[119]

cir-SHKBP1

Sponging miRNA -544a/miRNA -379

PI3K/AKT

Upregulated

Induces angiogenesis

[120]

CircPIP5K1A

Sponging miRNA -515-5p

TCF12 and PI3K/AKT

Upregulated

Induces proliferation, invasion, and EMT/Inhibited apoptosis

[205]

circ_0037655

Sponging miRNA -214

PI3K

Upregulation

Induces the viability and invasion of glioma cells

[206]

Circ_0000215

Sponging miRNA -495-3p

CXCR2/PI3K/Akt

Upregulated

Induces the proliferation, invasion and EMT/Inhibited apoptosis of glioma cells

[207]

circ-ITCH

Sponging miRNA -214

Wnt

Downregulated

Inhibited proliferation, invasion, and migration/Promoted the apoptosis

[129]

circ_0000177

Sponging miRNA -638

Wnt

Upregulated

Induces Proliferation, invasion, glioma growth malignant glioma behaviors

[131]

Circ_0043278

Sponged miRNA -638

Wnt

Upregulated

Promoted the cell migration, proliferation, and invasion

[132]

Circ 0,001,730

Sponged miRNA -326

Wnt/β-catenin

Upregulated

Induces the migration and proliferation of glioma cells

[136]

circ0082374

Sponging miRNA -326

Wnt/β-catenin

Upregulated

Induces viability, migration, invasion and glycolysis in glioma cells

[139]

circ-TTBK2

Sponging miRNA -217

MAPKs

Upregulated

Induces the cell proliferation, migration, and invasion/Inhibited apoptosis

[147]

circ-MAPK4

Sponging miRNA -125a-3p

MAPKs

Upregulated

Promoted survival and inhibited apoptosis

[150]

circASAP1

Sponging miRNA -502-5p

MAPKs

Upregulated

Promotes cell growth and inhibition of apoptosis

[151]

Circ-PITX1

Sponging miRNA -379-5p

MAPKs

Upregulated

Promoting the proliferation/Inhibit apoptosis

[152]

circ-ATXN1

Sponging miRNA -526b-3p

–

Upregulated

Increased glioma angiogenesis

[168]

circ ARF1

Sponging miRNA -342–3p

ERK

Upregulated

Induced angiogenesis

[170]

CircSMARCA5

–

–

Downregulated

Suppresses angiogenesis

[173]

circ-EPB41L5

Sponging miRNA -19a

circ-EPB41L5/miR-19a/EPB41L5/p-AKT

Downregulated

Inhibition the proliferation, invasion, migration, metastasis and tumorigenesis

[182]

hsa_circ_0008344

–

–

Upregulated

Induced cell migration, invasion and proliferation, and inhibition the apoptosis

[21]

circPARP4

Sponging miRNA -125a-5p

–

Upregulated

Promoted proliferation, migration, invasion, and EMT

[188]

Circ-UBAP2

Sponging miRNA -1205 and miRNA -382

–

Upregulated

Promoted cell proliferation, migration, invasion, and reduced apoptosis

[208]

hsa_circ_0046701

Sponging miRNA -142-3p

–

Upregulated

Promoted cell proliferation and invasion

[209]