|
CD44v6
|
Enhance migration and invasion
|
Activate Wnt/β-Catenin pathway and increase PAI-1, MMP and TIM-1
|
[44, 95, 96]
|
|
Tspan8
|
Promote signaling, apoptosis-resistance, angiogenesis, EMT, motility and invasion
|
Increase expression of chemokine and receptor
|
[44, 97]
|
|
MIF
|
Promote the formation of the liver pre-metastatic niche
|
Up-regulate TGF-β expression, KC and HSC activation and induce fibronectin secretion
|
[32]
|
|
Clandin7
|
Promote migration and invasion
|
Increase pAkt/Bcl-2/Bcl-XL/MDR1, promote matrix degradation, and reprogram SC and HPC
|
[48]
|
|
Lin28B
|
Promote the recruitment of PSC
|
Activate Lin28B/let-7/HMGA2 /PDGFB axis
|
[52]
|
|
GPC1
|
Inform pancreas cancer burden
|
Carry mutant Kras mRNA and HS modifications
|
[98,99,100]
|
|
C1QBP
|
HSC activation and liver fibrosis
|
Induce phosphorylation of the IGF-1 signaling molecule
|
[97]
|
|
Plectin
|
Induce migration, proliferation and invasion
|
Not mentioned
|
[80]
|
|
miR-1246
|
Promote PSC proliferation and pancreatic fibrosis
|
Induce Akt/ERK activation and increase α-SMA and procollagen type I C-peptide
|
[51, 97, 101]
|
|
miR-301a-3p
|
Promote metastasis and EMT
|
Mediate M2 macrophage polarization via PTEN/PI3Kγ
|
[102]
|
|
SRSF1
|
Regulate exosome microRNA enrichment
|
Direct binding to miR-1246 sequence
|
[86]
|
|
lnc-Sox2ot
|
Promote EMT and stem cell like properties
|
Bind to the miR-200 family
|
[101]
|
|
ITGs
|
Promote tumor-specific metastasis
|
Promote adhesion and activate genes
|
[33]
|
|
AEP
|
Enhance invasion and promote metastasis
|
Regulate activation of PI3K/AKT signaling
|
[102]
|
|
CKAP4
|
Proliferation and migration of PDAC cells
|
DKK1-dependent endocytosis routes
|
[103]
|
