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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Interleukin-1 receptor antagonist inhibits metastatic potential by down-regulating CXCL12/CXCR4 signaling axis in colorectal cancer

Fig. 2

Recombinant human Il-1α (rIL-1α) and colorectal cancer cell-derived IL-1α effect on secreted CXCL12 levels by fibroblasts. CXCL12 protein concentration in cultured medium of fibroblasts was determined by ELISA. rIL-1α and IL-1Ra effect on secreted CXCL12 levels by fibroblasts (A). Co-cultured with colorectal cancer cells (HT-29 or CaCo-2) or IL-1Ra influence secreted levels of CXCL12 by fibroblasts (B). The values are expressed as mean ± SD. Multiple comparisons were performed by one-way ANOVA followed by student–Newman–Keuls test, *P < 0.01

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Cell Communication and Signaling

ISSN: 1478-811X