Fig. 3
From: Cytoplasmic eIF6 promotes OSCC malignant behavior through AKT pathway
High expression of eIF6 can induce epithelial-mesenchymal transition, while knockdown of eIF6 reversed this process. (A) Transwell experiment was performed in HN4 and HN6 eIF6-transfected or NC-transfected cells (50 × magnification). eIF6 enhanced invasive capacity of OSCC cells. (B) The scratch assay was performed in HN4 and HN6 eIF6-transfected cells. (C) Transwell experiment was performed in HN4 and HN6 sh-eIF6-transfected or sh-NC-transfected cells (50 × magnification). (D) Wound healing experiment was demonstrated in sh-eIF6-transfected or sh-NC-transfected OSCC cells. (E) The relationship between high expression of eIF6 and EMT-related markers in HN4 and HN6 cells by western blot analysis. (F) Western blot analysis showed the effect of eIF6 knockdown on EMT in HN4 cells. All error bar values represent the SD. *P < 0.05, **P < 0.01, ***P < 0.001