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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Functional signaling test identifies HER2 negative breast cancer patients who may benefit from c-Met and pan-HER combination therapy

Fig. 4

Determining the IC50 values of pan-HER and c-MET inhibitors from a patient-derived sample (Patient R66) a Percent response of stimulation of NRG1b/EGF signal (two-growth factor cocktail) when treated with a 5-point, 1000-fold titration of the six indicated pan-HER antagonists, exponential log-scale fit with GraphPad Prism. b Percent response of stimulation of HGF signal when treated with a 5-point, 1000-fold dose response of the five indicated c-Met antagonists

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Cell Communication and Signaling

ISSN: 1478-811X