Fig. 9
PMVs improved pulmonary function via CTGF delivery. A HE staining of lung tissue treated by modified PMVs, the representative images are shown (n = 5, bar = 40 μm). B Wet weight to Dry weight ratio of lung in septic rats treated by modified PMVs (n = 8). C Cell count in BALF from septic rats treated by modified PMVs (n = 8). D Protein concentration in BALF from septic rats treated by modified PMVs (n = 8). E Serum TNF-α level in rats (n = 8). F Laser confocal microscopy analysis of FITC-BSA leakage in lung tissue treated by modified PMVs, the representative images are shown (n = 5, bar = 50 μm). G–J Blood gas analysis, including pH, pO2, pCO2, cLac (n = 8). Ctl: normal group; CLP: sepsis group; PMV: PMV-treated sepsis group; PMVCTGF−up: CTGF-upregulated PMV + sepsis group; PMVCTGF−down: CTGF-downregulated PMV + sepsis group; PMVvehicle: CTGF-mock-transfected PMV + sepsis group. ***P < 0.001, **P < 0.01, *P < 0.05