Fig. 8

PMV-delivered CD44 mediated the absorption of PMVs. A Laser confocal microscopy analysis of the absorption of VECs to PKH-26 labeled PMVs (n = 3, bar = 20 μm). B CCK8 proliferation of LPS-stimulated VECs treated by PMVs with anti-CD44 antibody (n = 6). C Scratch experiment of LPS-stimulated VECs treated by PMVs with anti-CD44 antibody, the representative images are shown (n = 5, bar = 100 μm). D Tube formation of LPS-stimulated VECs treated by PMVs with anti-CD44 antibody, the representative images are shown (n = 5, bar = 50 μm). E Statistical analysis of the tube length in D (n = 5). Ctl: normal group; LPS: LPS group; PMV: PMV-treated LPS group. Anti-CD44: Anti-CD44 blocking antibody (abcam, America). ***P < 0.001, **P < 0.01