Multiomic analysis on human cell model of wolfram syndrome reveals changes in mitochondrial morphology and function

Table 2 Summary of transcript-level Gene Set Enrichment Analysis across comparisons in transcriptomics analysis

Pathway	WFS versus healthy			WFS after tunicamycin versus WFS before			Healthy after tunicamycin versus healthy before
Reactome unfolded protein response UPR	↓	− 1.29	0.309	↑	2.25	0.001	↑	1.59	0.125
Reactome protein folding	↓	− 1.49	0.156	↓	− 1.00	0.751	↓	− 1.77	0.034
Reactome degradation of Gli1 by the proteasome	↓	− 1.65	0.092	↓	− 1.68	0.206	↓	− 1.81	0.029
Reactome mitochondrial protein import	↓	− 1.25	0.334	↓	− 1.09	0.750	↓	− 1.11	0.463
Reactome respiratory electron transport	↓	− 1.98	0.022	↓	− 1.63	0.201	↓	− 2.30	< 0.001

ISSN: 1478-811X