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Table 2 Summary of transcript-level Gene Set Enrichment Analysis across comparisons in transcriptomics analysis

From: Multiomic analysis on human cell model of wolfram syndrome reveals changes in mitochondrial morphology and function

Pathway WFS versus healthy WFS after tunicamycin versus WFS before Healthy after tunicamycin versus healthy before
Reactome unfolded protein response UPR  − 1.29 0.309 2.25 0.001 1.59 0.125
Reactome protein folding  − 1.49 0.156  − 1.00 0.751  − 1.77 0.034
Reactome degradation of Gli1 by the proteasome  − 1.65 0.092  − 1.68 0.206  − 1.81 0.029
Reactome mitochondrial protein import  − 1.25 0.334  − 1.09 0.750  − 1.11 0.463
Reactome respiratory electron transport  − 1.98 0.022  − 1.63 0.201  − 2.30  < 0.001