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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Estradiol increases risk of topoisomerase IIβ-mediated DNA strand breaks to initiate Xp11.2 translocation renal cell carcinoma

Fig. 7

E2-induced NRF1-dependent TFE3 expressions. A Correlation analysis of TFE3 mRNA level and serum E2 concentration in BalbC mice aged 4–10 weeks. B Statistics of TFE3 qPCR results in HK-2 cells under 0.1% DMSO (solvent-only control), 1 nM, 5 nM, 10 nM, 15 nM or 20 nM E2 treatment for 48 h. C Statistics of ESR1 qPCR results in E2-treated cells as in panel B. D Statistics of TFE3 qPCR results in HK-2 cells transfected with negative control shRNA (NC) or shRNA against NRF1 (shNRF1) under the same treatment as in panel B. E Statistics of NRF1 qPCR results in E2-treated cells as in panel D. Error bars indicate 95% confidence intervals (*p < 0.05; **p < 0.01; ***p < 0.001)

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Cell Communication and Signaling

ISSN: 1478-811X