From: Extracellular vesicles: mediators of intercellular communication in tissue injury and disease
Injury-causing agent | EV-secreting cell type | EV cargo changes | Effect on injury response | References |
---|---|---|---|---|
Docetaxel, doxorubicin | Breast cancer cells | ↑ miR-203a-3p | Induction of cancer stem cell characteristics | [46] |
↑ miR-9-5p | ||||
↑ miR-195-5p | ||||
Cytosine arabinoside | AML cells | ↑ HMGCR | Increased cholesterol production and proliferation in AML cells | [48] |
IR (6 Gy) | Head and neck cancer cells | ↑ FGFR1 | Enhanced migration and invasion in cancer cells; enhanced MMP-2 and MMP-9 expression | [74] |
↑ HSP90 | ||||
↓ KRT80 | ||||
↓ LAMP1 | ||||
IR (3 Gy) + hypoxia | Lung cancer cells | ↑ ANGPTL4 | Promotes migration and invasion in cancer cells; increased vascularization in endothelial cells | [77] |
Tobacco smoke | Macrophages | ↑ MMP-14 | Degradation of lung connective tissue in emphysema | [112] |