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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Beclin1 controls caspase-4 inflammsome activation and pyroptosis in mouse myocardial reperfusion-induced microvascular injury

Fig. 8

Autophagy regulates caspase-4 inflammasome and pyroptosis as cardiac microvascular endothelial cells (CMECs) responses to MI/R. A In resting CMECs, autophagy component beclin1 is complexed with caspase-4, inhibiting pyroptosis. B, C In response to I/R, caspase-4 inflammasome activation in CMECs, when caspase-4 inflammasome activation is exceeded, an increase in expression of beclin-1promotes autophagy activity to orchestrate caspase-4 activation and pyroptosis, which protects cells from I/R injury

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Cell Communication and Signaling

ISSN: 1478-811X