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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Beclin1 controls caspase-4 inflammsome activation and pyroptosis in mouse myocardial reperfusion-induced microvascular injury

Fig. 7

Beclin1 regulates autophagy flux through inhibiting caspase-4-mediated pyroptosis in CMECs. A, B Expression and quantification of LC3, P62, caspase-4 and GSDMD in CMECs cultured under normoxia or subjected to H/R (2/2 h). Data are expressed as mean ± SD (n = 3). *P < 0.05 vs. control group, #P < 0.05 vs. Len-GFP group, ## P < 0.05 vs. Len-GFP + H/R group. C Analysis of LDH release in CMECs under normoxia or 2 h hypoxia/ 2 h of re-oxygenation. Data are expressed as mean ± SD (n = 5). ##P < 0.05 vs. Len-GFP + H/R group. D, E Expression and quantification of LC3, P62, caspase-4 and GSDMD in CMECs cultured under subjected to H/R (2/2 h). Data are expressed as mean ± SD (n = 3). *P < 0.05 vs. Len-GFP + Baf group

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Cell Communication and Signaling

ISSN: 1478-811X