Fig. 7

Presenilin1 suppress MT and invasion of glioblastoma in vivo. A–C The gross observation of subcutaneous glioblastoma at day 21 post injection when over-expression of Presenilin1 or control, the volume of tumor was measured and calculated every three days after transplanting. D Western blot analysis of the activation of Sortilin/β-catenin axis and the expression levels of MT markers (N-cadherin, vimentin and MMP-2) in subcutaneous glioblastoma tissues. E Representative gross observations (scale bar = 5 mm) of orthotopic glioblastoma xenografts in the indicated groups. F The survival time of glioblastoma-bearing mice was analyzed by Kaplan–Meier method and compared by log-rank test. G H&E staining to show the invasion-growth states of orthotopic xenografts, dotted black line to show the border of glioblastoma. Scale bar = 50 μm. *p < 0.05, **p < 0.01