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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Presenilin1 inhibits glioblastoma cell invasiveness via promoting Sortilin cleavage

Fig. 6

Presenilin1represses MT and invasion though Sortilin/β-catenin axis in glioblastoma cell. A U87 and U251 cells were treated with Lv-PS1 alone, combined with Lv-Sort1 or with LiCl (Sortilin/β-catenin axis activator). Invaded cells were stained and counted using microscopy. B Transwell assays to investigate the invasion ability when down-regulation of Presenilin1, combined with Sortilin inhibitor AF38469 or with down-regulation of Sortilin in U87 and U251 cell. C Transwell assays to detect the invasion ability of U87 and U251 cells when treated with RO4909497 alone, combined with AF38469 or with down-regulation of Sortilin in U87 and U251 cell. D Western blot analysis of the expression levels of MT markers (N-cadherin, vimentin, MMP-2) in indicated groups of U87cells. Scale bar = 100 μm.**p < 0.01, *p < 0.05

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