Fig. 3

Presenilin1co-expresses and clearly co-localizes with Sortilin in glioblastoma cells. A-C The correlation of Presenilin1 with Sortilin from French-284-glioma dataset, Freije-85-gliomadataset and TCGA-540-glioblastoma dataset. D–F The relations of Presenilin1 with Sortilin frommRNAseq_325 dataset, mRNAseq_693 dataset andmRNA_array_301 dataset (contains all WHO grades primary glioma) on CGGA. G–I The relations of Presenilin1 with Sortilin from mRNAseq_325 dataset, mRNAseq_693 dataset andmRNA_array_301 dataset(contains all WHO grades recurrent glioma) on CGGA. J, K Proximity ligation assays (PLA) were performed on U87 and U251 cells, red spots indicate sites of PLA amplification, reflecting the Presenilin1-Sortilin co-location. Scale bar = 10 μm. The R and p value were downloaded and shown