Fig. 2
From: Presenilin1 inhibits glioblastoma cell invasiveness via promoting Sortilin cleavage
Presenilin1 represses mesenchymal transition of glioblastoma cell in vitro. A–D The correlations of Presenilin1 with mesenchymal transition transcription factors (Twist1, Twist2, Zeb1, Zeb2) from French-284-glioma dataset. The R and p values were downloaded and shown. E, F Western blot were performed to analysis the expression change of mesenchymal transition markers (Vimentin, N-cadherin and MMP2) inU87 and U251 cells when transfected with Lv-PS1, Sh-PS1 or control. G, H Representative cellular morphology change of U87 and U251 cell when transfected withLv-PS1, Sh-PS1 or control. Scale bar = 5 μm. The numbers of filopodia were calculated from five random image of each group and shown in histogram. **p < 0.01, *p < 0.05