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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Presenilin1 inhibits glioblastoma cell invasiveness via promoting Sortilin cleavage

Fig. 1

Presenilin1 inhibits migration and invasion of glioblastoma cell in vitro. A Kaplan–Meier analysis for all grade glioma patients. patients in the high Presenilin1 group (n = 131) and in the low Presenilin1 group (n = 131) (p = 0.0018, log-rank test). B–D Representative images of wound healing assays using U87 and U251 cells after over- or down-expression of Presenilin1. E–H Representative images of Transwell invasion assay using U87 and U251 cells transfected with Lv-PS1 and Sh-PS1. I, J Representative images of Transwell invasion assays using U87 and U251 cells after treated with Presenilin1 inhibitor RO4909497 (RO49). Quantification of wound healing assays were displayed on the right. Scale bar = 100 μm. **p < 0.01, *p < 0.05

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