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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension

Fig. 4

Profiling of protein kinases and phosphatases associated with CREB phosphorylation in MCT-induced PH. a, c Hierarchical clustering of the protein kinases and phosphatases related to CREB phosphorylation by using ClustVis. Rows in the heatmap represent averaged gene expression of replicates and columns represent time point. n = 3 MCT-treated rats at each time point and n = 5 control. b, d Heatmap of differentially expressed protein kinases and phosphatases induced by MCT. Rows in the heatmap represent gene expression levels and columns represent each sample. The DEGs between control and MCTW4 were identified by using a threshold of fold change ≥ 2 and p ≤ 0.05. Ctr, control; MCTW1, MCTW2, MCTW3 and MCTW4 represent MCT treatment for 1, 2, 3 and 4 weeks, respectively

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Cell Communication and Signaling

ISSN: 1478-811X