Fig. 4
From: NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis
INTS11 depletion in EAC OE19 causes apoptosis. a–d INTS11 knockdown results in decreased tumor cell viability and increased apoptosis as determined by flow cytometry using PI and AnnexinV. Bars represent standard deviation (the mean from 4 biological replicates). *p < 0.05; **p < 0.01 versus CTR sample. e Representative WB shows an overexpression of pro-apoptotic markers BAK1 and cleaved PARP and a decreased expression of an anti-apoptotic BCLXL. f–h INTS11 knockdown results in G2/M cell cycle arrest as evident from the flow cytometry analysis. Bars represent standard deviation (the mean from 4 biological replicates). **p < 0.01 versus CTR sample