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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis

Fig. 3

INT is required for Notch-dependent cell growth and tumorigenesis in EAC. a Integrator subunits are overexpressed in several EAC cell lines as compared to the non-tumorigenic esophageal cell line Het1A (representative WB). b, c INTS11 knockdown results in EAC cell growth arrest in a colony formation assay (representative assay). d OE33 xenografts size is significantly decreased upon INTS11 knockdown compared to the control xenografts shGFP OE33. Bars represent standard deviation (N = 6). **p < 0.01 versus CTR sample

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Cell Communication and Signaling

ISSN: 1478-811X