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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells

Fig. 7

RRAS and RRAS2 differentially promote proliferation and migration in ST88-14 cells. a Real-time PCR assays for RRAS (left panel) and RRAS2 (right panel) mRNAs in ST88-14 cells transduced with lentiviruses expressing a non-targeting control shRNA (NT), RRAS shRNAs (RRasA, RRasB) or RRAS2 shRNAs (RRas2A, RRas2B). b RRAS and RRAS2 knockdown both potently inhibit the migration of ST88-14 MPNST cells. c RRAS2, but not RRAS, knockdown inhibits the proliferation of ST88-14 cells. d Both RRAS and RRAS2 knockdown inhibit the phosphorylation of MYPT1 and ROCK1. Quantification indicated below the blots represents the ratio of the normalized phosphorylated to total protein levels

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Cell Communication and Signaling

ISSN: 1478-811X