Fig. 4

Distinct networks of phosphorylated proteins are affected by DN R-Ras expression. a The global distribution of heavy (DN R-Ras) to light (uninduced) ratios of detected phosphoproteins in ST88-14 MPNST cells. Plotted values are log₂(H:L). Note that the phosphorylation of the vast majority of detected proteins are unaffected by DN R-Ras expression. b IPA analysis identified thirteen networks affected by DN R-Ras induction with IPA scores ≥ 16; the seven top ranked networks are shown. The proteins in the top seven networks whose phosphorylation is altered by DN R-Ras expression are presented in Table 2