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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Role of autophagy on cancer immune escape

Fig. 2

Autophagy regulates MHC-I/II stability. MHC-1/II plays a critical role in antigen presentation for T cell activation and killing, while MHC-I/II undergoes autophagic degradation in cancer cells by NBR1 or March1 leading to tumor immune escape. In addition, AAK1 induces MHC-1 autophagic degradation in DCs resulting in inhibition of antigen presentation and T cell activation

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Cell Communication and Signaling

ISSN: 1478-811X