Fig. 5
From: Cellular dynamics of EMT: lessons from live in vivo imaging of embryonic development
Cadherin 6 regulates active Rho GTPase distribution, F-actin accumulation, and apical detachment in zebrafish neural crest cells during EMT. A Wild-type zebrafish pre-migratory neural crest cells (NCCs) show an apical accumulation of active Rho GTPases and filamentous actin (F-actin), which are necessary for actomyosin-mediated apical detachment and subsequent lateral migration during EMT. B In most Cadherin 6 knockdown NCCs, F-actin fails to accumulate in the apical tail, active Rho is more widely distributed, the apical tail does not detach, and the cells do not undergo EMT or initiate migration [85]