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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Cellular dynamics of EMT: lessons from live in vivo imaging of embryonic development

Fig. 1

Overview of EMT and MET transitions. Epithelial-mesenchymal transition (EMT) is a dynamic process in which cells turn on EMT-promoting transcription factors (EMT-TFs), disassemble cell–cell junctions, lose apical-basal polarity, and upregulate new cadherins. Cells also undergo extensive rearrangements of actin cytoskeleton that mediate shape changes, front-rear polarity, invasive behavior, and migration. In many cases in vivo, EMT is partial and cells have both epithelial and mesenchymal properties. A mesenchymal-epithelial transition (MET) is the reverse process

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