Skip to main content
Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Extracellular vesicles derived from glioblastoma promote proliferation and migration of neural progenitor cells via PI3K-Akt pathway

Fig. 5

Proteomic analysis of U87 EVs-treated mNPCs revealed the activation of PI3K-Akt-mTOR pathway. A Proteomic analysis revealed 187 upregulated proteins and 147 downregulated proteins in U87-EVs-treated mNPCs compared with control mNPCs. B The distribution of changed proteins in U87-EVs-treated mNPCs. C Top 10 biology processes of upregulated proteins revealed by Gene Ontology analysis in U87-EVs-treated mNPCs revealed. D Top 10 biology processes of downregulated proteins in U87-EVs-treated mNPCs revealed by Gene Ontology analysis. E Top 10 signaling pathways of upregulated proteins in U87-EVs-treated mNPCs revealed by KEGG analysis. F Top 10 signaling pathways of downregulated proteins in U87-EVs-treated mNPCs revealed by KEGG analysis. G Western blotting confirmation of upregulated PI3K-Akt-mTOR pathway proteins in U87-EVs-treated mNPCs. Results are presented as the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001, in comparison with 0 h

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X