Fig. 5

Combinational therapy of 17AAG and LMB significantly inhibits the malignant proliferation of CML cells. a, b CCK-8 assay compared the effects of 17AAG with the effects of 17AAG combined with LMB on the proliferation of K562 and K562/G01 cells. c, d To observe the effect of drug combination on cell proliferation ability in clone formation experiments and count the number of colonies after being treated with 10 μM 17AAG combined with 10 nM LMB for 5 days. e Effects of activation of Bcr-Abl and downstream signaling molecules in K562 and K562/G01 cells were associated with the use of 10 μM 17AAG combined with 10 nM LMB. *p < 0.05, **p < 0.01 and ***p < 0.001