Fig. 3

CKO mice exhibit a pro-inflammatory phenotype. a The percentage of initial body weight change, after 10 weeks normal (ND) and high-fat diet (HFD) feeding. n = 12 in WT-ND; n = 6 in WT-HFD, CKO-ND and CKO-HFD. Results are presented as mean ± SE ***p < 0.001 compared to WT. b H&E staining of brown adipose tissue of WT and CKO mice. c CKO mouse inflammatory phenotype observed in the heart, adipose tissue and brain. d Human CRABP1 expression data. Reduced CRABP1 expression in various inflammatory disease conditions. Results are presented as *p value ≤ 0.05; **p value ≤ 0.01; ***p value ≤ 0.001; ****p value ≤ 0.0001. [34,35,36,37,38]