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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: The phosphatase Shp1 interacts with and dephosphorylates cortactin to inhibit invadopodia function

Fig. 8

In vivo imaging of lung metastases in a A375MM wild-type and Shp1-kd mouse models after GroPIns treatment. A Representative images of fluorescence reflectance imaging (FRI) of BALB/c nude mice bearing A375MM-derived lung metastases treated with PBS (Control; 6 mice) or GroPIns (50 mg/kg; 6 mice) 5 days/week for 2 weeks. After treatment, mice were i.v. injected with 2 nmol of ProSense 750 and after 24 h they were subjected to imaging studies by FMT 4000. B Quantification of Cathepsin activatable fluorescent probe (expressed as counts/energy) of animals treated as in A. C Representative ex vivo images of the lungs excised from control and GroPIns-treated mice after in vivo imaging. D Representative images of FRI of BALB/c nude mice bearing A375MM Shp1-kd-derived lung metastases treated with PBS (Control; 4 mice) or GroPIns (50 mg/kg; 4 mice) 5 days/week for 2 weeks. After treatment, mice were i.v. injected with 2 nmol of ProSense 750 and after 24 h they were subjected to imaging studies by FMT 4000. E Quantification of Cathepsin activatable fluorescent probe (expressed as counts/energy) of animals treated as in D. F Representative ex vivo images of the lungs excised from control and GroPIns-treated mice after in vivo imaging. ***P < 0.001 (Student’s t-test) calculated for each treatment versus untreated samples

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