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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Bone morphogenetic protein receptor 2 inhibition destabilizes microtubules promoting the activation of lysosomes and cell death of lung cancer cells

Fig. 4

Inhibition of BMPR2 activates lysosomes in sensitive lung cancer cell lines but not in MDA-MB-468 cells. A Immunofluorescence imaging of LAMP1 in treated A549 cells treated with JL5. (B-C) Immunofluorescence imaging for Lysotracker™ Green and Green Cathepsin B of A549 treated with JL5 for 24 h. D Immunofluorescence imaging of Lysotracker™ Green of H1299 treated with JL5. E Immunofluorescence imaging for LAMP1 and Lysotracker™ Green of cells treated with DMH1 for 24 h. F–G Immunofluorescence imaging for Lysotracker™ Green and Green Cathepsin B of A549 cells transfected with control or BMPR2 siRNA for 48 h. H, I Immunofluorescence imaging for Lysotracker™ Green and LAMP1 of MDA-MB-468 cells treated for 24 h with JL5. (J-K) Immunofluorescence imaging Lysotracker™ Green of H1299 and MDA-MD-468 cells treated with Ym155 for 24 h. Each scale bar represents 10 μM

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