Skip to main content
Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Bone morphogenetic protein receptor 2 inhibition destabilizes microtubules promoting the activation of lysosomes and cell death of lung cancer cells

Fig. 3

JL5 induces trafficking of BMPR2 from the plasma membrane in sensitive lung cancer cell lines but not in resistant MDA-MB-468 cells. A Immunofluorescence imaging of BMPR2 on the plasma membrane treated with vehicle control or JL5 for 24 h. B Quantification of fluorescent intensity of BMPR2 on the plasma membrane after treatment with JL5 reported as the percent decrease in comparison to vehicle control. C Dual immunofluorescent staining for LAMP1 and BMPR2 24 h following treatment with JL5 and Ym155 alone and in combination. Arrows demonstrate co-localization of BMPR2 with LAMP1. D Co-localization of LAMP1 was quantified using Image J. *p < 0.05. Each scale bar represents 10 μM

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X