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Table 2 Proteins related to the cNLS-mediated protein transport mechanism

From: Types of nuclear localization signals and mechanisms of protein import into the nucleus

Component Other names Function
Importin α Karyopherin α Adaptor that links cNLS-cargo to importin β1
Importin β Karyopherin β Transport factor that carries the cargo protein through the NPC
Ran Gsp1* Ras-superfamily GTPase that coordinates protein–protein interactions
CAS Cse1* A nuclear export factor dependent on importin α
RanGAP Ran1* GTPase-activating protein
RanGEF RCC1 Guanine nucleotide exchange factor
Nup50 NPap60 Acts as a molecular ratchet that prevents futile cycles
  1. *in Saccharomyces cerevisiae. NLS nuclear localization signal, NPC nuclear pore complex