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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: The extracellular HDAC6 ZnF UBP domain modulates the actin network and post-translational modifications of Tau

Fig. 4

Enhancement of podosome formation by HDAC6. a Podosomes marked by actin rich structures along plasma membrane, were observed in neuro2a cells at a minimal level. b Enhancement in podosome like structures observed in HDAC6 ZnF UBP treated cells. Orthogonal projection images showed marked difference in membrane morphology and actin concentrated in membrane ruffles and podosome like structures in HDAC6 ZnF UBP treated cells. c HDAC6 is found to be present in neuritic extensions along with actin suggesting its role in regulation of neurite extensions. This is not seen in case of untreated cells as indicated in enlarged images for both groups. d In HDAC6 ZnF UBP treated cells, F-actin containing longer extensions were observed. Growth cones were observed to be concentrated in membrane extensions and filopodia-like structures

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Cell Communication and Signaling

ISSN: 1478-811X