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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: The extracellular HDAC6 ZnF UBP domain modulates the actin network and post-translational modifications of Tau

Fig. 1

Downregulation of GSK-3β activity by HDAC6. a Neuro2a mapped for total GSK-3β shows their unaltered levels upon HDAC6 ZnF UBP. b Inhibitory phosphorylation of GSK-3β at Ser9 increases upon HDAC6 ZnF UBP treatment. The enlarged image shows the elevated level of pGSK-3β compared to neuro2a cell control. c Quantification of mean fluorescence intensity for GSK-3β in cell control and HDAC6 ZnF UBP treated cells showed non-significant difference while the levels of pGSK-3β were significantly increased upon HDAC6 ZnF UBP treatment in comparison to cell control

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Cell Communication and Signaling

ISSN: 1478-811X