Fig. 7
From: ATF5 and HIF1α cooperatively activate HIF1 signaling pathway in esophageal cancer
Silencing of ATF5 inhibited tumor angiogenesis and tumor proliferation in vivo. a The tumor growth curve among the four groups; p < 0.01. b, c Representative tumor images among the four groups (b), the right graph is showing the weight of the tumor (c); p < 0.01. d, e. Representative IHC staining of the identified protein among the four groups; the right graph showing the micro-vessel density of the tumors in the groups; Scale bar 100 μm. f Western blot assay showing the expression levels of the identified proteins in xenograft tumors. g Proposed model: ATF5/HIF1α interaction enhancing the binding of the HIF1 transcriptional complex on the promoters of the HIF1 target genes