Fig. 6
From: ATF5 and HIF1α cooperatively activate HIF1 signaling pathway in esophageal cancer
Inhibition ATF5 phenocopies HIF1α knockdown in tumorigenic properties in vitro. a The gene sequence of a dominant-negative ATF5 (D/N-ATF5). b Western blot showing the expression levels of the identified proteins in hypoxia. c Dual-luciferase assay showing the activation ability of identified gene promoters in identified cells in hypoxia; p < 0.01. d CCK8 assay showing the proliferation ability of identified cells in hypoxia; p < 0.01. e Transwell assay showing the invasion and migration ability of the identified cells in hypoxia; Scale bar 100 μm. f Tube formation ability of HUVECs induced by supernatant from medium of identified the cells in hypoxia; Scale bar 100 μm; p < 0.01