Fig. 3
From: Methylation as a key regulator of Tau aggregation and neuronal health in Alzheimer’s disease
Cross talk of methylation with other PTMs. Cross-talk between methylation, acetylation and ubiquitination may occur over the modification of a specific common lysine residue. Acetyl transferases, methyl transferases and ubiquitin ligase carry out respective modification and works synergistically with histone deacetylases (HDACs), demethylases and deubiquitinating enzymes (DUBs) respectively. Methylation has an indirect cross-talk with phosphorylation as protein phosphatase 2A (PP2A) is activated through methylation and functions to reduce the hyperphosphorylation of Tau