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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Discovery of LAMP-2A as potential biomarkers for glioblastoma development by modulating apoptosis through N-CoR degradation

Fig. 7

CMA blockage promoted N-CoR accumulation and suppressed tumorigenesis of glioma in vivo. a Representative image of xenograft tumors grown in nude mice injected with differently treated U87-MG cells. LAMP-2A shRNA (LAMP-2A shR) group showed significantly smaller tumors than those in control shRNA (CT-shR) group. b Continuous measurements of tumor volumes. The difference of tumor volumes between LAMP-2A shR and CT-shR group on Day 12 and 15 was insignificant. From post-implantation Day 18 till last measurement, the tumor volumes were significantly decreased in LAMP-2A shR group. c The final tumor weight after mice sacrifice was significantly lower in LAMP-2A shRNA group as compared with CT-shR group; D. Western blot analysis of LAMP-2A and N-CoR expression from tumor tissues of differently treated mice. Decreased LAMP-2A and increased N-CoR expression were observed in LAMP-2A shR group compared with CT-shR group; E. Immunohistochemistry analysis of N-CoR (brown signal) from tumor tissues of differently treated mice. Increased N-CoR expression was observed in LAMP-2A shR group compared with CT-shR group. The results were in accordance with the findings from clinical samples and in vitro study. The data are mean ± SEM from three mice as a group. Significant changes are set as p < 0.05 and represented by asterisk (One-Way ANOVA; Bonferroni's test)

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Cell Communication and Signaling

ISSN: 1478-811X